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The author is not a physician. The content on this website does not, and is not intended to constitute medical advice. It should not be relied upon when making medical decisions. It is not intended as a substitute for advice from your physician or other healthcare provider.

August 19, 2008

Sodium borohydride (Medium reducing)

Category: Synthesis

Sodium borohydride is intermediate to the jackhammer that is LAH and the pussycat that is cyanoborohydride.

August 13, 2008

Perchloroethylene (Oddly ubiqutious)

Category: Poisons

Trying to think of a molecule tonight, my friend suggested "pick an ugly one no one wants anymore...a clearance rack molecule." I immediately went to chlorinated solvents. They're in the backwater now, right? Carbon tetrachloride sure has a bad rep. I figured most of the organochlorides, except for the ubiquitous lab solvents, would, too. I was wrong.

August 11, 2008

Pyrene (Photo-neat)

Category: Dyes

Pyrene is a simple, four-fused benzene PAH:

August 7, 2008

Dewy Propionate (Funny functional group names)

Category: Perfumey

I love reading lists of fragrance chemicals. The assignment of pleasant, qualitative fragrance descriptions to chemicals with hard-nosed, rigorous functional group names always makes me giggle a little. Acetophenone, for instance, smells of orange blossoms. Today, I came across one that has both in the name: dewy propionate:

August 5, 2008

Vote and help kids...

Category: Not Really a Molecule

If you have been reading SB long enough to remember the DonorsChoose promotion, you might be interested in this. It's videos of scientists talking about their first experiments and why they like science, and if you vote on the one you like best, DC gets a buck. Check it out here.

August 4, 2008

Erythorbic Acid (President Bush have a less-carcinogenic hotdog with me)

Category: Food

Erythorbic acid is a common food additive:

July 29, 2008

Nardil/Phenelzine (Hydrazine chases the blues away)

Category: Drugs

As I mentioned yesterday, derivatives of arylethylamines - phenethylamine in particular - are drug targets in depression, but a sophisticated mechanistic understanding remains elusive. When you have some idea what molecule you'd like less of, a favorite trick is to find something (an "inhibitor") that binds to some enzyme in the pathway to your molecule and mucks up the works.

July 28, 2008

Reserpine (Depressing antihypertension medication)

Category: Drugs

An aromatic ring, two carbons, and a nitrogen will get you a lot of places.From hallucinogens to decongestants to speed, the arylethylamine moiety works because it tickles neurotransmitter receptors. The effects of the assorted monoamine neurotransmitters are as varied as those of the drugs that mimic it - hypertensive, euphoriant, the works. This is part of how we try to explain to ourselves how antidepressants that block the breakdown of these neurotransmitters (MAO inhibitors) or their reuptake (SSRIs) might be working. What might happen if you took something that depleted some of those monoamine neurotransmitters?

July 24, 2008

Choline Chloride (Vitamin or solvent?)

Category:

Choline is an ubiquitous vitamin. Interestingly, it makes a number of "deep-melting eutectics" with other dirt-common chemicals like Urea.

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