Placental peptide reverses symptoms of preeclampsia

 

File:LitterMom1480.jpg Wikimedia, Whatiguana

Preeclampsia is a serious complication that develops in about 5-8% of pregnant women. It is characterized by elevated blood pressure and is typically accompanied by excess protein in the urine (a sign of kidney problems). Symptoms often (but not always) return to normal after delivery of the baby.

Elabela is a recently discovered micropeptide secreted by the placenta in mammals. It is also found in fish where it plays a role in development of the heart. A recent study published in Science showed that mice that do not have this peptide develop preeclampsia. When researchers administered Elabela to mice with preeclampsia, they discovered that the micropeptide reversed hypertension and the presence of proteins in the urine. According to a quote from lead study author Dr. Bruno Reversade published in The Scientist, “We are able to rescue all these clinical symptoms by administering synthetic Ela[bela] in the knockout mice, so it’s not just that we have a new model [of preeclampsia], we have a potential therapeutic.”

Sources:
L Ho, M Van Dijk, STJ Chye, DM Messerschmidt, SC Chng, S Ong, LK Yi, S Boussata, GH-Y Goh, GB Afink, CY Lim, NR Dunn, D Solter, BB Knowles, B Reversade. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. doi: 10.1126/science.aam6607, 2017.
The Scientist

More like this

Image of chicken egg from Wikimedia Commons.
Both Twisty and Amanda seem a bit weirded out by this
After a newborn (born to a mother infected with the 2019 novel coronavirus disease (COVID-19) testing positive for COVID-19 infection within 36 hours of birth, there were concerns about whether the virus could be contracted in the womb.
Before I head for Utah, let me direct your attention to two articles of mine in tomorrow's New York Times. They don't have a whole lot in common except they are examples of cool biology...