Genetic Association

Genes which affect female development

razib | May 18, 2009

There are several papers and letters in Nature Genetics on the relationship between menarche, menopause, etc. and genetics. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche: We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 10-9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 10-9), which also influences adult height. We provide the first…

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