New drugs & treatments
edyong | December 29, 2009Many of us have just spent the Christmas season with a persistent and irritating ringing noise in our ears. But now that the relatives have gone home for the year, it's worth remembering that a large proportion of the population suffers from a more persistent ringing sensation - tinnitus. It happens in the absence of noise, it's one of the most common symptoms of hearing disorders, and it's loud enough to affect the quality of life of around 1-3% of the population.
There have been many suggested treatments but none of them have become firmly established and most simply try to help people…
edyong | April 29, 2009HIV is an elusive adversary. The virus is so good at fooling the immune system that the quest for an HIV vaccine, or even a countermeasure to resist infections, has spanned two fruitless decades. But maybe a defence has been lurking in our genomes all this time.
Nitya Venkataraman from the University of Central Florida has managed to reawaken a guardian gene that has been lying dormant in our genomes for 7 million years. These genes, known as retrocyclins, protect monkeys from HIV-like viruses. The hope is that by rousing them from their slumber, they could do the same for us. The technique…
edyong | January 18, 2009
You swallow the pill. As it works its way through your digestive system, it slowly releases its chemical payload, which travels through your bloodstream to your brain. A biochemical chain reaction begins. Old disused nerve cells spring into action and form new connections with each other. And amazingly, lost memories start to flood back.
The idea of a pill for memory loss sounds like pure science-fiction. But scientists from the Massachussetts Institute for Technology have taken a first important step to making it a reality, at least for mice.
Andre Fischer and colleagues managed to restore…
edyong | January 16, 2009
Using genetic engineering, a group of scientists have developed a way of sneaking a virus past the brain's defences. Don't panic - this isn't some nightmare scenario. It could be the first step to curing a huge number of brain diseases.
The brain seems incredibly well protected amid its shell of bone and cushioning fluid. But even the strongest of forts needs supply lines, and brain is no exception.
A dense network of blood vessels carries vital oxygen to its cells. These vessels are a potential vulnerable spot, providing access for bacteria and other disease-causing organisms to migrate…
edyong | December 13, 2008When normal bacteria are exposed to a drug, those that become resistant gain a huge and obvious advantage. Bacteria are notoriously quick to seize upon such evolutionary advantages and resistant strains rapidly outgrow the normal ones. Drug-resistant bacteria pose an enormous potential threat to public health and their numbers are increasing. MRSA for example, has become a bit of a media darling in Britain's scare-mongering tabloids. More worryingly, researchers have recently discovered a strain of tuberculosis resistant to all the drugs used to treat the disease.
New antibiotics are…
edyong | November 10, 2008If you're anything like me, then you will find that the onset of spring is a time of great rejoicing and equally great woe. The longer days, rising temperatures and greening world also signal the arrival of pollen, microscopic granules of hell determined to make you breathe fresh air only in the short spaces between sneezes, and enjoy the increasingly beautiful world through watery eyes.
But help is at hand. Allergens in the air can cause misery for about a third of people in Western countries, but a new clinical trial suggests that injecting allergens directly into someone's lymph nodes can…
edyong | August 16, 2008
Imagine reading the paper to find that a new wonder drug has been created that could save your life, if only you could afford it. Alternatively, put yourself in the shoes of the authorities that must decide not to offer powerful new drugs on the NHS because they simply aren't cost-effective enough. These situations are all too common-place and are often due to the extremely high costs of drug development. But a couple of years ago, scientists at Icon Genetics and Bayer Bioscience made an exciting step toward lowering these costs for some of the most promising new treatments.
The…
edyong | August 4, 2008For the first time, scientists have developed drugs that mimics the effects of endurance exercise. With the aid of two chemicals, Vihang Narkar, Ronald Evans and colleagues from the Salk Institute managed to turn regular lab rodents into furry Paula Radcliffes - mighty mice that were capable of running further and for longer than their peers. One of the drugs only worked in combination with exercise, but the other managed to boost stamina without it.
Using drugs to boost performance isn't a new development. Steroids can help body-builders to build their bodies, while giving athletes an extra…
edyong | June 28, 2008
In the final months of 2001, five people died because they opened their mail. The killers were hidden inside the envelopes, small spores that were inhaled by the unfortunate addresses. Inside their bodies, the spores turned into the deadly bacteria, Bacillus anthracis - anthrax.
Anthrax has a long history in biological warfare but it made its debut as an agent of bioterror in 2001. The US anthrax postal attacks infected 22 people and claimed the lives of five. Since then, scientists have been feverishly studying the bacteria responsible in the hope that better understanding will lead to…
edyong | June 21, 2008
The world's nations are stockpiling two drugs, Tamiflu and Relenza, to counter the threat of a bird flu pandemic. These drugs work by blocking a key protein that allows the virus to spread. But two years ago, a study revealed the structure of this protein and in doing so, shown that both Tamiflu and Relenza only work through a fortunate fluke.
The threat of bird flu is looming large in the minds of the public, scientists and politicians alike. So far, 241 people have died of the disease across 12 countries. But the real worry is that that the virus could mutate into a form that passes…
edyong | April 11, 2008For comic book characters, big doses of radiation are a surefire way of acquiring awesome superpowers, but in real life, the results aren't quite as glamorous. A victim of acute radiation poisoning can look forward to hair loss, bleeding, the destruction of their white blood cells and bone marrow, and severe damage to their spleen, stomach and intestines.
Radiation doesn't kill cells directly, but it can cause so much damage that they commit suicide, by enacting a failsafe program called apoptosis. Now, Lyudmila Burdelya and colleagues from Roswell Park Cancer Institute have found a way to…
edyong | March 16, 2008
Tropical parasitic diseases may lack the headline-grabbing power of bird flu or SARS and they may fail to grab the pharmaceutical industry's attention. But there is no doubt that they are a massive problem. Schistosomiasis, a disease that many people in Western countries will never have heard of, currently afflicts 3% of the world's population, a staggering 20 million people, and almost four times that number are at risk.
Schistosomiasis, also known as bilharzia, affects people living across the tropics. It's caused by parasitic flatworms called blood-flukes, belonging to the genus…