serotonin transporter gene
ddobbs | April 1, 2010
After I wrote in my Atlantic article about getting my serotonin transporter gene assayed (which revealed that I carry that gene's apparently more plastic short-short form), I started getting a lot of email â several a week â from readers asking how to have their SERT gene tested. This led to an interesting hunt.
It was a hard question to answer. I couldn't just tell people to do what I did, for a psychiatric researcher/MD I'd known for years, who specializes in depression and serotonin, had done mine as a sort of favor to science and journalism. That researcher also stood by, had I needed…
ddobbs | March 9, 2010
Jonah Lehrer's story on "Depression's Upside" has created quite a kerfuffle. The idea he explores â that depression creates an analytic, ruminative focus that generates useful insight â sits badly with quite a few people. It's not a brand-new idea, by any means; as Jonah notes, it goes back at least to Aristotle. But Jonah (who â disclosure department â is a friend; plus I write for the Times Magazine, where the piece was published) has stirred the pot with an update drawing from (among other things) a very long review paper published last year by psychiatric researchers Paul Andrews and J…
I'm not vulnerable, just especially plastic. Risk genes, environment, and evolution, in the Atlantic
ddobbs | November 10, 2009
The video interview above, with NIH primatologist Stephen Suomi, is embedded within a feature of mine that that appeared today at The Atlantic website -- and is in the December 2009 issue now shipping -- about a new hypothesis in behavioral genetics.
This emerging hypothesis, which draws on substantial data, much of which has gone simply unnoticed or unremarked, I call the "orchid-gene hypothesis," for lack of a better name. Some of the researchers have other offerings. It's been around for several years but is now blooming as evidence accumulates. When I came across it at a conference this…
ddobbs | June 17, 2009Big psych news of the day is that a big JAMA study debunked the "depression gene" -- that is, this big new study (by Risch et alia, in JAMA, today) found that, contrary to a famous earlier big study (Caspi et alia, in Science, 2003), the short ("bad") form of a particular gene called 5-HTT does NOT make a person more vulnerable to depression. Or, to flip it:: Caspi 2003 had found that having a short version of 5-HTT, which affects processing of serotonin, put someone at more risk of depression if they experienced (as adults) repeated stressful life events. Risch 2009, crunching data from a…