The DNA Sequencing Wars

Yesterday, I mentioned that one of the greatest technological developments that contributed to the evolution of population genetics was the automation of DNA sequencing. I was unaware, however, that the automated DNA sequencing method that most people use was patented by a group from Caltech (including Leroy Hood) in 1998. The actual invention was conceived in the early 1980s, but a competing group claims they came up with the idea first according to this article in the NYTimes.

If Enzo Biochem, the group suing Caltech over the patent, were to win their lawsuit, companies such as Applied Biosystems (which makes many of the DNA sequencers used in genetics labs) would need to redirect their royalty payments to Enzo. I guess this could affect the price of DNA sequencing machines that employ the dye termination method, but I'm not sure what the implications for research would be. This does not have any affect on alternative sequencing strategies (such as 454), which may make traditional Sanger sequencing obsolete.

More like this

No more delays! BLAST away! Time to blast. Let's see what it means for sequences to be similar.  First, we'll plan our experiment.  When I think about digital biology experiments, I organize the steps in the following way: 
Shotgun sequencing refers to the process whereby a genome is sequenced and assembled with no prior information regarding the genomic location of any of the DNA we sequence. There are quite a few steps that you have to go through before you have an assembled genome sequence.
A few weeks back, we published a review about the development and role of the human reference genome. A key point of the reference genome is that it is not a single sequence.
What tells us that this new form of H1N1 is swine flu and not regular old human flu or avian flu? If we had a lab, we might use antibodies, but when you're a digital biologist, you use a computer.