Seroquel antagonizes serotonin, dopamine, and histamine, but it doesn't look a whole lot like any of these:
The benzothiazepene (benzene fused to the seven-membered ring containing nitrogen and sulfur) ring system bears a little resemblance to the benzodiazepines, the class to which Valium belongs, but sulfur and nitrogen are completely different kettles of fish from almost every standpoint - not to mention the rest of the ligand, particularly the piperazine (six-membered ring containing two nitrogens) moiety.
Seroquel finds use as an antipsychotic, along with numerous off-label uses.
More like this
So what does heartburn have to do with diabetes? Funny you should ask. Big Pharma giant AstraZeneca is being sued by 15,000 people who claim that their atypical antipsychotic, Seroquel, causes diabetes.
I'm having difficulty even reading, much less posting about, the river of stories about pharma and device industries, FDA regs, conflicts of interest, and so on. But I'll take a stab here at spotlighting the main events and making some sense of where this is headed.
For
anyone who is interested, Medscape has a nice, concise
href="http://www.medscape.com/viewarticle/554128">summary
article about medication treatment options for bipolar
Every so often, I get an email from someone who is seeking advice on some medical issue. For example, I received this short message a few days ago:
Little pink pills...to be taken in the evening...