I write about lots of things on ERV, but I didnt anticipate ever getting to the point where I can write new blog posts on new publications by cutting and pasting from old blog posts on old papers...
Lots of news outlets have been talking about this new paper:
Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence
Ive covered the themes of this paper several times in the past.
This paper is more data to support some older ideas in HIV. While I dont quite understand the media frenzy, with HIV, you cant ever assume things or take old ideas for granted, so I am quite happy they performed this work.
More like this
Student guest post by Francis Mawanda.
When someone is dying, you treat what is killing them first.
For some reason, pop news became enamored with this paper last month (unfortunately while I was away at a conference):
HIV infection en route to endogenization: two cases
HIV diagnosis is The Root of most of the problems we have in HIV World.
"How can we get more people antiretrovirals?"... How can you give someone antiretrovirals before they have been diagnosed with HIV?
I've been kind of surprised that antivaccine crank Cynthia "CIA" Parker hasn't stapled this to her freak flag yet. I wish I had noticed Fig. S3D earlier.
I read somewhere( Peter Cresswell,December 23, 2014, The first step of peptide selection in antigen presentation by MHC classI molecules) that the MHC class I molecules select and present a limited set of antigen peptides from a vast that are provided. So MHC class I molecules technically go through rounds of considering and rejecting peptides until peptides with high affinity are acquired for presentation. This explains the effect on the progression of HIV.
15073883
How do you get tested for which MHC molecule you have?