Whipworm parasite reduces symptoms of autism

Image from www.Nematode.net.
Credit: http://www.latech.edu/ans/faculty-staff/liberatos-james-d/parasite-pict…

Believe it or not, scientists at Albert Einstein College of Medicine in collaboration with Coronado Biosciences are intentionally infecting people who have autism with whipworms from pigs (Trichuris suis), although generally considered non-pathogenic to humans.

For some individuals, an elevated inflammatory state contributes to repetitive and irritable behaviors associated with autism. Researchers have observed that allergic responses (measured by skin prick tests) are higher in people who had received anti-parasitic therapies. Therefore, parasites may actually reduce inflammation and activate pathways that regulate immune responses. In fact, neurobiologist Dr. Paul Patterson (California Institute of Technology) noted that epidemiological evidence suggests there is an increased prevalence of autoimmune diseases in families that have autistic members.

I was surprised to learn that the idea of trying this radical therapy came, not from a scientist, but from the father of an autistic boy. This idea was featured in The Scientist. The father administered whipworm eggs to his son (under the supervision of Dr. Eric Hollander now at Albert Einstein) and noted reduced autistic behaviors.

Following the success of this case study, Dr. Hollander will now conduct a double-blind trial of 10 young adults with autism. Half of the group will receive a placebo and the other half will receive the parasite eggs (Trichuris suis ova) for 12 weeks. The groups will then go through a 2 week wash-out period to allow the parasite to clear from the digestive tract at which point the groups will receive the alternative treatment (a crossover design).

The suggestion above that 2 weeks will allow the parasite to clear is intriguing as that suggests that this particular parasite may need to be administered chronically in order to have sustained effects.

Source:
The Scientist