The upside of herpes - when one infection protects against another


Blogging on Peer-Reviewed ResearchWhen people say that every cloud has a silver lining, they probably aren't thinking about herpes at the time. Herpes may be unpleasant, but the viruses that cause it and related diseases could have a bright side. In mice at least, they provide resistance against bacteria, including the bubonic plague.

i-d4e716d84bd69d947c8a93f9fa31bfb0-herpes_labialis.jpgHerpes is one of a number of itchy, blistering diseases, caused by the group of viruses aptly-named herpesviruses. Eight members infect humans and cause a range of illnesses including glandular fever, chickenpox, shingles and, of course, herpes itself.

Almost everyone gets infected by one of these eight during their childhood. But herpesviruses are for life, not just for Christmas. After your body fights off the initial infection, the virus retreats into a dormant phase known as 'latency'. It remains hidden and causes no symptoms, but has the potential to reactivate at a later date. In this way, herpesviruses can seem like life-long parasites, ensuring their own survival at the cost of their host's future health. In extreme cases, latent viruses can lead to chronic inflammation, which in turn can cause autoimmune diseases, or some types of cancer.

But there is a bright side too. Erik Barton and colleagues from Washington University Medical School found that once infected mice entered the latent stage, they were surprisingly resistant to certain types of bacteria. Unlike their vulnerable uninfected peers, they even managed to ward off the deadly plague bug, Yersinia pestis.

At least in mice, latent herpesviruses turn out to be paying tenants rather than free-loading squatters - bacterial resistance is their rent. The latent stage is crucial to the resistance effect, and Barton found that a mutant herpesvirus that infects but doesn't set up shop provides no benefits to its host.

The viruses work their magic by putting the immune system on high alert. The effect is similar to a raising of the terror alert creating a heightened level of security where the body is prepared to fight off any further threats.The viruses trigger the release of high levels of immune system chemicals called cytokines. These molecules - including interferon-gamma (IFN-g) and tumour necrosis factor alpha (TNF-a) - help to co-ordinate the defence against infections.

These chemicals activate macrophages - a type of white blood cell. These cellular assassins engulf invading bacteria, and sentence them to death by digestion. And in mice latently infected by herpesviruses, they are activated in bulk. This sequence is similar to the way the immune system normally protects us against multiple bacterial invaders. But in Barton's experiments, the protection was set off by viruses instead, and lasted for much longer than normal.

All well and good for the mice, but do these viruses benefit us too? Barton thinks so. In his study, two very different strains - murine gammaherpesvirus 68 (gHV68) and murine cytomegalovirus (MCMV) - had the same effect. He believes that providing bacterial resistance is a general property of all herpesviruses.

There is certainly growing evidence to support his claims. If many people, the latent viruses reactivate regularly, but not strongly enough to cause major symptoms. In these cases, doctors have seen higher levels of cytokines and long-term activation of the immune system, just like Barton saw in his mice.

Barton even suggests that herpesvirus infection may play a role in protecting against allergies. According to the 'hygeine hypothesis', infections during childhood prime the immune system against future threats. By depriving children of these experiences, overly clean homes can lead to naïve immune systems that react disproportionately to harmless things like pollen. Allergies are the result.

It isn't clear what role herpesviruses play in priming the immune system. But at least one study found that people who are infected with the Epstein-Barr herpesvirus (EBV) are less likely to show sensitive antibody reactions to allergens in their environment. Clearly, the subject is a rich vein for further research.

Almost everyone has had an encounter with a herpesvirus of some kind. They cause a wide range of diseases, but could they be protecting us from many more?

Reference: Barton, White, Cathelyn, Brett-McClellan, Engle, Diamond, Miller & Virgin IV. 2007. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447: 326-330.

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Alternately, the chronic inflammatory state that they induce could be a risk factor for other conditions such as atherosclerosis. Chronic inflammation is a known risk for all sorts of nasties.

By D. C. Sessions (not verified) on 21 Feb 2009 #permalink

Being a total ignorant here so apologies for the dumb question...

What if rather than contracting the condition, mice/apes/"your fave mammalian species" is inoculated against it. Does it make a difference?

By Miguel Silva (not verified) on 21 Feb 2009 #permalink

I might prefer the plague. I can get antibiotics. . . or am I missing something?

Of course, the punchline would be if your lover gave you BOTH!

Pretty interesting article. I hear a lot about chronic inflammation from my chiropractor...this article doesn't really relate to chronic inflammation, but I wonder if raising the "terror alert" for extra years of your life takes a toll on your system. Seems like it must. Not that there's that much we can do about it...

Anyway, couple typos there Ed. You have an "If" where I think you need an "In" and transposed the i and e in hygiene (but managed to get the link right).

Perhaps it's worth mentioning, in passing, that eating lots of cheese (say 100g/day) and avoiding nuts and peanuts can keep herpes outbreaks away.

There's an interesting story behind how this works, that I haven't found primary sources for, yet. Ed might be able to help.

By Nathan Myers (not verified) on 21 Feb 2009 #permalink

It should also be noted that high levels of cytokines are what killed 50-100 million people during the World War I Flu Plague. High cytokines aren't necessarily a good thing.

Evolution in action.

The host what lives the longest infects the mostest.

Similar to Lillian:
How will anti-HPV/cervical cancer vaccines effect this (Gardasil, Cervarix).

Damn complex immune system.

The body continues to do amazing things. I guess the balance of helpful and harmful will always exist. It's always ironic though, that the things we believe are dangerous seem to come back to help in the end (but at a cost). Give some, get some.

Thanks for the post. It was very interesting!

Herpes may be unpleasant, but the viruses that cause it and related diseases could have a bright side. So it's useful for someting else?

CDC estimates that 19 million new infections occur each year, almost half of them among young people ages 15 to 24.

The number on increase by 20%, while Cases of HIV/AIDS
increase by 13% in 2009 in USA.