Bioethics
oracknows | March 13, 2011Progress in science-based medicine depends upon human experimentation. Scientists can do the most fantastic translational research in the world, starting with elegant hypotheses, tested through in vitro and biochemical experiments, after which they are tested in animals. They can understand disease mechanisms to the individual amino acid level in a protein or nucleotide in a DNA molecule. However, without human testing, they will never know if the end result of all that elegant science will actually do what it is intended to do and to make real human patients better. They will never know if…
oracknows | February 10, 2011
Judge Orders Surgery For Teen Wrestler: MyFoxPHILLY.com
I have to be honest here. I don't know for sure what I think of the latest developments in the Mazeratti Mitchell case.
As you may recall from a couple of days ago, Mazeratti Mitchell is a 16 year old wrestler in Philadelphia who suffered a spinal cord injury while wrestling. Fortunately, given his subsequent course in which he has been recovering function, it was clearly not a complete transection of the spinal cord, but it was severe. His doctors recommended surgery to stabilize his spine and allow his injured spinal cord to heal.…
oracknows | November 23, 2010They call it the Nobel disease.
Linus Pauling is the prototypical example. A brilliant chemist who won two Nobel Prizes, one for chemistry and the Nobel Peace Prize, in his later years Pauling became convinced that high dose vitamin C was a highly effective treatment for cancer and the common cold and, expanding upon that, came to believe in the quackery that is orthomolecular medicine. As a result, Pauling's reputation was tainted for all time, and he became known more for his crankery than his successes. Since his death, Pauling's successors have continued to chase his dream with minimal…
oracknows | November 2, 2010One of the great things about having declared Vaccine Awareness Week is that it gives me a convenient excuse to revisit topics and blog posts that I had meant to address but that somehow didn't make the cut the first time around. This is the sort of thing that happens fairly frequently in blogging, where there is far too much woo and idiocy for one blogger to have even a hope of ever addressing it all.
And that's just the anti-vaccine movement.
In any case, if there's one thing about the anti-vaccine movement that I've noticed, it's that its members have a very warped view of both science and…
cagapakis | October 24, 2010Nick pointed me to a fabulous podcast series by CBC radio called "How To Think About Science." Each episode is a long and fascinating interview with a prominent scholar of science--scientists, philosophers, sociologists, anthropologists, and historians who explore how science is done, how scientists work, and how scientific ideas and facts are communicated. Check it out!
oracknows | October 4, 2010If there's one thing that burns me about so-called "complementary and alternative medicine" (CAM) clinical trials, it's how unethical many of them are. This is particularly true for trials that test modalities that, on the basic science grounds alone, can be dismissed as so highly implausible and with such a low prior probability of success that it is unethical to subject patients to risk with close to zero potential for benefit. Perhaps the most egregious example of such a clinical trial is the Gonzalez protocol in pancreatic cancer, a cornucopia of woo and quackery including up to 150…
oracknows | September 20, 2010A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted while in SBM it is not, particularly for therapies that are wildly improbable strictly on the basis of basic science, but for both the randomized clinical trial remains, in essence, where the "rubber…
cagapakis | July 20, 2010Everyone's favorite Slovenian philsopher, Slavoj Žižek, discussing his provocative perspective on nature, ecology, biotechnology, and climate change while dumpster diving:
via Immanent Discursivity (thanks Nick!)
sb admin | July 7, 2010As I said yesterday on Twitter, a big conflict of interest and transparency problem has arisen on ScienceBlogs. Like several other bloggers here, I'm now on a hiatus, however like like David Dobb's and Blake Stacy's, my hiatus from ScienceBlogs will be permanent. I've been contemplating a move from ScienceBlogs for a while for several reasons, but PepsiGate has sealed the deal for me. Several of my ScienceBlogs colleagues have summed up the situation well, including PZ Myers, GrrlScientist, and Brian over at Laelaps. For a full recap of the issue and other ScienceBloggers' responses, see…
rskloot | July 7, 2010As I said yesterday on Twitter, a big conflict of interest and transparency problem has arisen on ScienceBlogs. Like several other bloggers here, I'm now on a hiatus, however like like David Dobb's and Blake Stacy's, my hiatus from ScienceBlogs will be permanent. I've been contemplating a move from ScienceBlogs for a while for several reasons, but PepsiGate has sealed the deal for me. Several of my ScienceBlogs colleagues have summed up the situation well, including PZ Myers, GrrlScientist, and Brian over at Laelaps. For a full recap of the issue and other ScienceBloggers' responses, see…
sb admin | July 2, 2010I've been working for a while to develop a Frequently Asked Questions page to answers the most common reader questions about The Immortal Life of Henrietta Lacks. Well, it's now online, and it addresses questions ranging from why HeLa cells are immortal to how the Lacks family is benefiting from the book. It also includes answers to commonly asked publishing questions, like, How do I break into science writing? You can read it online here. If you have burning questions not answered there, leave them in the comments section below -- I'll add to the FAQ as questions arise and time allows.
sb admin | July 1, 2010A press release landed in my inbox today with this headline, which raised my eyebrows (as it was obviously intended to do): "First Experiment to Attempt Prevention of Homosexuality in Womb." It starts with this quote from Alice Dreger, a Northwestern University bioethicist: "This is the first we know in the history of medicine that clinicians are actively trying to prevent homosexuality." The release was announcing the publication of a piece at the Hastings Center Bioethics Forum titled, "Preventing Homosexuality (and Uppity Women) in the Womb? -- it was written by the same authors that…
rskloot | July 1, 2010A press release landed in my inbox today with this headline, which raised my eyebrows (as it was obviously intended to do): "First Experiment to Attempt Prevention of Homosexuality in Womb." It starts with this quote from Alice Dreger, a Northwestern University bioethicist: "This is the first we know in the history of medicine that clinicians are actively trying to prevent homosexuality." The release was announcing the publication of a piece at the Hastings Center Bioethics Forum titled, "Preventing Homosexuality (and Uppity Women) in the Womb? -- it was written by the same authors that…
cagapakis | June 8, 2010
In a recent conversation about the safety and ethics of synthetic biology in the wake of the announcement of the synthetic genome, many of the professors I was chatting with commented on how they hoped new synthetic biology technology would lead to bacteria that could eat the oil spilling into the gulf of mexico even as I type this right now. Of course, the "technology" for oil eating bacteria already exists and have already been used for clean up in previous oil spills--many naturally occurring species of bacteria can already break down the hydrocarbons in crude oil. The natural oil eaters…
cagapakis | June 2, 2010Biosafety has been on everyone's mind this week after the announcement of the J. Craig Venter Institute's successful transplantation of a synthetic genome. What horrible pathogen will future bioengineers be able to design? What unforeseeable environmental catastrophe will befall us upon the release of genetically engineered bacteria? These are hugely important questions as research in synthetic biology moves forward, being discussed in congressional hearings and as an integral part of every new synthetic biology design.
As the major proposed goal of a great deal of synthetic biology research…
cagapakis | June 1, 2010I'm realizing that perhaps in yesterday's post I took everyone's love and understanding of postmodern feminist theory for granted so I'm going to start a little series of posts that I think will slowly introduce some of the issues that I spend a lot of time thinking about and hope that other people will too. Today I'm going to jump right into it by posting the essay I wrote for a horrible class I took about science and religion called Belief Options for a Practicing Scientist. The assignment was to write a five page essay on what the best belief option for a scientist is and why. I think that…
sb admin | May 31, 2010Anyone interested in Henrietta Lacks and the grave marker finally placed on her long unmarked grave this weekend should click here immediately for a beautiful post by scientist David Kroll, who attended the unveiling ceremony. It's filled with beautiful photos of the day, and a tribute to all Henrietta's cells did for science. His photo below shows Henrietta's new headstone in much sharper detail than the one I posted yesterday with the text of the inscription. Visit his post for many more photos of the ceremony, the graveyard, and Henrietta's family.
terrasig | May 31, 2010
In addition to my own photos herein, Tom McLaughlin posted a nice slide show of the day at his South Boston News & Record.
Despite two trees that snapped and fell in my driveway within six feet of my car in an impressive thunderstorm Friday evening, I drove on Saturday morning to Clover, Virginia, for the dedication of a gravestone that finally marks the final resting place of Henrietta Lacks, a concrete honor, if you will, to recognize the source of one of the most valuable medical tools of the 20th century and today.
For those who are not regular readers, Henrietta Lacks was a rural…
sb admin | May 29, 2010Today is a very exciting day: Henrietta Lacks (aka HeLa) has been lying in an unmarked grave since her death in 1951. Today, thanks to Dr. Roland Pattillo at Morehouse School of Medicine, who donated a headstone after reading The Immortal Life of Henrietta Lacks, her grave is finally marked. Below, a snapshot of some members of the Lacks family beside the new marker for Henrietta, and the marker for her daughter, Elsie, which was also unveiled today. Dr. Roland Pattillo is pictured at the far left:
Her stone, in case you can't tell from the picture, is shaped like a book. The text was…
rskloot | May 29, 2010Today is a very exciting day: Henrietta Lacks (aka HeLa) has been lying in an unmarked grave since her death in 1951. Today, thanks to Dr. Roland Pattillo at Morehouse School of Medicine, who donated a headstone after reading The Immortal Life of Henrietta Lacks, her grave is finally marked. Below, a snapshot of some members of the Lacks family beside the new marker for Henrietta, and the marker for her daughter, Elsie, which was also unveiled today. Dr. Roland Pattillo is pictured at the far left:
Her stone, in case you can't tell from the picture, is shaped like a book. The text was…