Clinical trials
terrasig | July 26, 2007When readers are looking for clinical trials information, particularly for cancer therapies, I often refer to the NIH-operated clinicaltrials.gov:
ClinicalTrials.gov provides regularly updated information about federally and privately supported clinical research in human volunteers. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details. The information provided on ClinicalTrials.gov should be used in conjunction with advice from health care professionals.
The other day, I accidentally typed in clinicaltrials.org.…
oracknows | July 23, 2007After the invasion of the smoking cranks last week into the comments of the three posts I somehow ended up doing on the topic of secondhand smoke (SHS), the health dangers it poses, and some of the deceptive quote mining used in the service of trying to discredit studies demonstrating a moderate but real risk from SHS , I was ready to move on to other topics. I'll give these guys credit for one thing; they're almost as persistent as the antivaccinationists. Despite my flooding this blog with fluff unrelated to smoking and the hazards it causes (or even, for that matter, medicine or surgery),…
oracknows | July 20, 2007It sure took the FDA long enough, nearly five months, but it finally acted. It finally shut Jim Tassano down, as this notice on TheDCASite.com states:
Two agents from the FDA visited us on Tuesday,July 17, 2007 and ordered that we stop making and selling DCA. Unfortunately, the site www.buydca.com will be shut down immediately.
It is against US government law to sell substances with the suggestion that they are cancer treatments unless they are approved by the FDA.
DCA can still be obtained from pharmacies with a prescription and from chemical companies.
To keep you informed and abreast of…
oracknows | July 19, 2007Little did I know when I posted my first article on the evidence supporting health hazards due to secondhand smoke that it would end up dominating the comments of this blog for three full days and lead me to a site that's so full of pseudoscience, logical fallacies, and just plain B.S. that it is worthy of the title of the Whale.to of the tobacco nuts. Even less did I expect that the crankfest would spread to fellow SBer Mark's denialism blog as well. The sheer vitriol that some of these "smoking rights" advocates direct at any suggestion that SHS might be harmful, quite frankly, took me…
oracknows | July 17, 2007Not surprisingly, in response to my article on the health risks of secondhand smoke yesterday, the "skeptics' came out in force, although I must admit that even I hadn't expected quite as large an influx as what appeared. Perhaps I'll prepare a general response in the near future (and, no, I didn't take the Surgeon General's report as the be-all and end-all, but it did make a compelling case for SHS causing increasing the risk of lung cancer and cardiovascular disease at least, and it also served as a convenient aggregator of the many, many studies out there). In the meantime one commenter…
oracknows | July 12, 2007It looks as though I've been tagged by Drug Monkey, who apparently thinks that I might have something worth saying about the state of the NIH and its peer review system, about which the NIH is presently soliciting comments, as pointed out to me by Medical Writing, Editing, & Grantsmanship. Why Drugmonkey might think this to be the case, I have no idea, but presumably it has something to do with some previous posts that I've made about the NIH, how biomedical research is funded in this country, and the disconnect between vision and reality at the highest level of the NIH. Although I used…
oracknows | June 20, 2007Having exhausted myself for the time being on two things that irritate me a lot (namely creationist neurosurgeon Dr. Michael Egnor and the antivaccination pseudoscience being presented as "evidence" that vaccines cause autism at the Autism Omnibus), it's time for a change of pace. For all my tendency to deride certain "alternative medicine" modalities as pseudoscientific nonsense (homeopathy, anyone?), you may have noticed that I tend to take a softer line with acupuncture. No, it's not because I'm a believer. Certainly, I don't buy for a minute that somehow sticking needles in "meridians" in…
terrasig | June 11, 2007As I noted in a previous post on arsenic trioxide, you just never know what source will give rise to the next promising drug. Last week's New England Journal of Medicine marked a key study on an old drug, mitotane (Lysodren, Bristol-Myers Squibb), that is a structural derivative of the pesticide, DDT.
Adrenocortical carcinoma is a rare cancer with only 16-38% of patients surviving for five years. Following surgical resection, 75-85% of patients experience a relapse. Therefore, a group of Italian and German researchers sought to identify drugs that could be used as adjunct therapy in this…
oracknows | June 11, 2007Dedicated advocate of evidence-based medicine that I am, I am sometimes labeled by those who do not understand skepticism as a "shill" for big pharma. Of course, such accusations are simply the logical fallacy known as poisoning the well, in which the credulous engage in preemptive ad hominem attacks designed to associate me with the hated big pharma, but it's a common enough tactic that sometimes I can't help but joke that I wish pharma did actually pay me for my little hobby here. After all, why do for free (or for a pittance from my Seed overlords) what, if you believe the alties, I could…
oracknows | June 7, 2007As I mentioned a few days ago, I was at the ASCO Meeting over the weekend, arriving home Tuesday evening. ASCO has to be, as far as I can tell, the largest cancer meeting in the world. How big? 30,000 or so attendees big. Hundreds of sessions and talks big. Filling most of McCormick Center in Chicago big. Filling most hotel rooms in the city of Chicago big. Or, as these photos show, this big:
And, to reflect the hugeness of the meeting, the exhibit hall is enormous:
As is the hugeness of many of the drug company displays...
Although I couldn't really take pictures of it (too dark…
oracknows | June 4, 2007It's day three of the ASCO Meeting here in Chicago.
So far, I have to say, it's been a bit underwhelming. Unlike some years past, there don't appear to have been any real blockbuster results to report; rather, lots of incremental studies were presented. There's really only one study presented that I might blog, mainly because it relates to posts that I did before about early detection of cancer and using MRI to screen for breast cancer, but that will probably have to wait until tomorrow or after I get back. In this impression, I don't appear to be alone, as Dr. Len Lichtenfield, the CEO of…
terrasig | June 3, 2007Yesterday morning's press release from the American Society for Clinical Oncology (ASCO) meeting included discussion of three abstracts on complementary therapies being tested in cancer and cancer-related indications. The highlights on the major news services are that 1) a shark cartilage extract failed to provide survival benefit in patients with non-small cell lung cancer, 2) an American ginseng extract reduced cancer-related fatigue, and 3) flaxseed slows prostate cancer growth.
Just a few comments, mostly on the positive results, that didn't make it into mainstream media reports:
The…
oracknows | May 30, 2007I love it.
You see I noticed an old "friend," the Herbinator, making this comment about me regarding dichloroacetate:
I was listening to CBC Radio - the Current, as is my want, and there was a show on about DCA, or Dichloroacetic acid. DCA is a molecule so simple and cheap to make that drug companies are unable to patent it ... so they simply pass on researching it. Some say that DCA is a most excellent and effective cancer treatment.
I have to confess that I had never heard of DCA before. And so I perked an ear toward listening to the radio show as simplicity itself and uppity people…
oracknows | May 29, 2007It never seems to end, does it?
I'm talking about the hype and questionable practices revolving around dichloroacetate (DCA), the small molecule chemotherapeutic agent that targets the Warburg effect, in essence normalizing the metabolism of tumor cells and thereby inhibiting their growth. (See here and here for more details.) A report by Evangelos Michelakis at the University of Alberta in Cancer Cell in January reported strong antitumor activity against a wide variety of tumors in rat tumor models resulted in a phenomenon ballooning out of control in a way that he could never have imagined…
oracknows | May 27, 2007Over the last couple of months, I've written periodically about cancer research and the complaints that the present system of funding grants and of peer review stifles innovation, as well as whether ideas for which there is some evidence but which fall out of the mainstream are given a fair shake. My overall take has been that, while the complaints have some merit, those making them tend to overstate their case dramatically. Either that, or their obvious agendas, such as making it easier to get funding for pseudoscience or rehabilitating the reputation of a crank, make it obvious that their…
oracknows | May 25, 2007I've been meaning to go through the recent meta-analysis of Avandia published by the New England Journal of Medicine that purported to show major increase in the risk for cardiac events (myocardial infarctions and cardiac death) in patients who use Avandia, but somehow never got around to it. I'm not sure I need to now, given how, via Kevin, MD, I've found this rant byThe Angry Pharmacist, who has looked over the meta-analysis and found that there is considerably less there than meets the eye and that the value of the study is considerably different than what has been reported in the press.…
oracknows | May 24, 2007Our creationist neurosurgeon, Dr. Michael Egnor, isn't going to like this one bit. No doubt he'll try to call it "artificial selection" or a "tautology" when he finds out about it, if he doesn't just ignore it because he it doesn't fit in with his view that studying evolution is "of no value" in medicine. Too bad, because, via Derek Lowe at In the Pipeline, I've found a really cool application of evolutionary biology to the development of antibiotic resistance in response to vancomycin that sheds light on the molecular mechanisms behind the development of antibiotic resistance in…
oracknows | May 22, 2007I've complained on multiple occasions about the infiltration of non-evidence-based "medicine" (a.k.a. woo) into every level of medicine in the U.S.. Worst of all, it's infiltrating medical education in a big way, starting with the pro-woo activism of the American Medical Student Association (AMSA), to various educational programs in various medical schools, to even the mandatory medical curriculum in at least one prestigious medical school. This is more than just teaching what various "alternative medical" therapies are, so that new physicians know what their patients are referring to or…
oracknows | May 21, 2007I hadn't planned on revisiting this topic again quite so soon, but sometimes a piece of information comes up that's so disturbing that I can't ignore it and can't justify delaying blogging about it by very long. So it is yet again with the strange and disturbing saga of dichloroacetate (DCA), the small molecular chemotherapeutic drug with a novel and scientifically interesting mechanism of action that could lead to a whole new class of chemotherapeutic agents and that has shown considerable promise in rat tumor models but has not yet been tested in humans. Not to belabor the story, which has…
oracknows | May 16, 2007One of the favorite targets of pseudoscientists is the peer review system. After all, it's the system through which scientists submit their manuscripts describing their scientific findings or their grant proposals to their peers for an evaluation to determine whether they are scientifically meritorious enough to be published or to be funded. Creationists hate it. HIV/AIDS denialists hate it. Indeed, pseudoscientists and cranks of all stripes hate it. There's a reason for that, of course, namely that vigorous peer review is a major part of science that keeps pseudoscientists from attaining the…