CNTNAP2 & language

Anthropology.net & prefonal both have posts up which survey a new paper, A Functional Genetic Link between Distinct Developmental Language Disorders:

We found that FOXP2 binds to and dramatically down-regulates CNTNAP2, a gene that encodes a neurexin and is expressed in the developing human cortex. On analyzing CNTNAP2 polymorphisms in children with typical specific language impairment, we detected significant quantitative associations with nonsense-word repetition, a heritable behavioral marker of this disorder (peak association, P=5.0x10-5 at SNP rs17236239). Intriguingly, this region coincides with one associated with language delays in children with autism.

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Today, a new paper published in Nature adds another chapter to the story of FOXP2, a gene with important roles in speech and language. The FOXP2 story is a fascinating tale that I covered in New Scientist last year.