The transparent biological society

FuturePundit has some musings on the possiblities of $100 genome sequencing in 5 years:

Cheap portable DNA sequencers will also lead to surreptitious DNA sequencing of people without their awareness. I expect to see this on the dating and bar scene. I also expect to see it in job interview and business negotiation situations. Check to see if your potential employee or business partner has genes that give them cognitive traits to avoid or embrace.

To be frank, this seems to b aiming too low. After all, why look to genetic profiles which suggest potentialities or probabilities? If you can get a biological sample could you not simply directly assay for a specific biochemical state? What I'm saying is that if you are looking for a particular cognitive profile, a better bet than genes might be to simply calculate the chemical state at a given moment.

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A few weeks back, we published a review about the development and role of the human reference genome. A key point of the reference genome is that it is not a single sequence.
What tells us that this new form of H1N1 is swine flu and not regular old human flu or avian flu? If we had a lab, we might use antibodies, but when you're a digital biologist, you use a computer.

Can you elaborate on the nature of these "biochemical states", and how the can be used to "measure" certain things about an individual (like a cognitive profile or whatever)?

Can you elaborate on the nature of these "biochemical states", and how the can be used to "measure" certain things about an individual (like a cognitive profile or whatever)?

i'm thinking of dopamine levels and what not. i don't know how big of a blood sample you'd need for that, but it would be better to get just get the levels of a chemical X, then the genes which produce the chemicals.

and of course many men would benefit from biochemical clues that "she's just not into" them :-) dudes aren't the best at reading faces & mannerisms.

I guess it depends how much information you can get about the relevant biochemistry from an available biological sample. You can get DNA pretty easily from a discarded glass or cigarette butt, but I suspect it would be pretty difficult (if not impossible) to get an accurate picture of neurotransmitter levels from the same type of trace sample.

But in principle I agree - information about proximal biochemistry (which integrates over both genetic and environmental causes) would be preferable to more distantly associated genetic profiles, if you can get it.