In 16th century France, there lived a king with a beautiful and somewhat mysterious mistress.Â Diane de Poitiers was almost 20 years older than Henri II but she looked like one of his contemporaries. She had skin of a near porcelain white and auburn hair as fine as silk thread.
Famed for her intellect as well as her beauty, Diane was not only the king's lover but one of his closest political advisors. He even encouraged her to sign some of his official correspondence HenriDiane.Â After Henri died in 1559, his angry and resentful widow banished Diane from the court. She died at the age of 66,Â seven years later at the Chateau d'Anet in northern France, a palace given to her by the enamored monarch. Her body was laid to rest near the castle's chapel and it stayed there until the French Revolution (1787-1799) when revolutionaries dug it up and threw it into a ditch used for pauper burials.
And there they stayed until a few years ago, when the burial pit was uncovered and Diane de Portiers skeleton was identified (matching it through facial reconstruction and through a break in one leg, that she had sustained in a fall from a horse).
But the archeologists also noted that her bones were unusually thin and fragile-looking, especially for a woman famed in her time as an athletic woman who swam daily and enjoyed vigorous horseback rides.
Suspecting a heavy metal poisoning of some kind and remembering that some locks of her hair were preserved at Chateau d'Anet, they requested a toxicology screen. The analysis came back showing the hair loaded with metal, but definitely not one of the usual suspects: de Poitiers' hair contained the precious metal gold at 500 times above normal levels
"Her hair was much finer than normal, which is a secondary effect of chronic gold poisoning," reported French researcher Philippe Charlier."It gives you white skin (from anemia) and very fragile hair, bones and teeth. She was in this fragile state when she died."
But why would de Portiers's body contain such high levels of a precious metal? It was unlikely that she dined on her jewelry. Further research discovered that she was in the habit of drinking a gold elixir, prescribed by apothecaries of the time as a means of preserving youthfulness. The elixir contained gold chloride (AuCl3, one atom of gold for every three of chlorine) dissolved into a solvent.
We'll look more specifically at gold and its poisonous properties tomorrow. For today, it's worth noting that, given our current understanding, Diane de Portiers' youthful vigor could well have been due to her health exercise habits. Her famously pale skin, though, was undoubtedly due to gold poisoning.
And although she lived a reasonably long life - 66 was definite elder status in the 1500s - the conclusion of the French researchers who dug up her bones is that she probably would have lived even longer, if she hadn't poisoned herself with gold.
Cool. A long time ago, I gave someone a gold injection for her arthritis. I was scared to death because it was viscous and just looked like it was going to hurt. I used an injection technique called a Z track where the top layer of skin is pulled sharply to the side, then the injection is given before snapping the skin back in place to seal the hole so the stuff didn't leak into the superficial tissues above the muscle. I still remember it. Scary.
Ouch. But really interesting because I want to talk about gold in medicine tomorrow.