Clinical trials
oracknows | May 10, 2017Over the last couple of days, I've been writing about two incredibly bad "studies" by Anthony Mawson, an antivaccinationist and Andrew Wakefield fanboi, who first published one of them in a bottom-feeding predatory open access journal and saw it retracted. Then he appears to have divided the study up two minimal publishable units and had them published as two papers in a bottom-feeding predatory open access journal even lower on the food chain that the first, after having promoted its second coming among the antivaccine crowd. Obviously, I'm not going to go into the details of each study's…
oracknows | May 7, 2017Some posts I really enjoy doing. I'm so fired up by the topic that the words flow, and I finish a post in record time. Other posts are more of a chore, written not so much because I'm excited by the topic, but because I feel duty bound to address it. I feel the need to write such posts when, for example, a bit of pseudoscience has gained traction in mainstream groups and readers keep writing me about it, to the point where I finally give in. This is one of the latter posts. None of this is to say that I don't still do my best with these posts to explain and argue my points. Fear not, I'll get…
oracknows | May 1, 2017"Integrative medicine" is a term for a form of medicine in which pseudoscience and quackery are "integrated" with real medicine. Unfortunately, as Mark Crislip puts it, when you mix cow pie with apple pie, it doesn't make the cow pie better; it makes the apple pie worse. Unfortunately these days, there's a lot of cow pie being mixed with apple pie. Worse, it's gotten to the point where integrative medicine is subspecializing. For instance, there is now a specialty known as "integrative oncology," which particularly burns me. Indeed, supportive care oncology has been very susceptible to the…
The failure of the Texas Medical Board: Houston cancer quack Stanislaw Burzynski is back in business
oracknows | April 26, 2017When last I wrote about Houston cancer quack Dr. Stanislaw Burzynski nearly two months ago, he had, as I characterized it, just mostly slithered away from justice once again. The Texas Medical Board had not removed his license and had only fined him relatively lightly given his offenses. True, he had conditions placed on his continued practice (more on that later), but it hasn't slowed him down, as you will soon see. Another family is raising funds, this time from the UK, to travel to Houston for his nostrums. Basically, by failing to revoke Stanislaw Burzynski's medical license, the Texas…
oracknows | April 23, 2017Anyone who has been reading this blog for the last three years or so knows that I'm not a fan of "right-to-try" laws. Basically such laws, which have sprung up like kudzu since 2014 and now exist in 33 states, purport to allow terminally ill patients the "right to try" experimental therapeutics. Thus far, they have been sold to the public as giving terminally ill patients "one last shot" and touting how such laws could save lives. As a result, as I've grimly quipped on multiple occasions, to politicians opposing right-to-try laws is akin to opposing motherhood, apple pie, and the American…
oracknows | April 16, 2017From the moment that Donald Trump was unexpectedly elected President, I couldn't help but be concerned about what President Trump would mean for medical science and science in general. I was not alone in my concerns. Of course, now, five months later, we know that such concerns were quite valid. If funding is a primary indicator, then, if anything, my concerns expressed last November were understated. For example, in his first budget, Trump proposed cutting the National Institutes of Health (NIH) budget by 19%, and, then, not content with that, proposed cutting $1.2 billion from this fiscal…
oracknows | March 17, 2017Among quacks, epigenetics is the new quantum theory.
I know I've said that before, but it's worth saying again in response to a new quack I've just discovered, courtesy of an article in The Daily Mail Fail by one Dr. Sara Gottfried pimping her books and health empire, From taking a sauna to drinking pinot noir, a fascinating book by a hormone doctor reveals how to... switch off your bad genes and live longer.
Epigenetics. She's talking about epigenetics. Of course, she keeps using that word. I do not think it means what she thinks it means. Indeed, if what's in this article is a taste of what…
oracknows | March 8, 2017I've been writing about a phenomenon that I like to refer to as "quackademic medicine," defined as the infiltration into academic medical centers and medical school of unscientific and pseudoscientific treatment modalities that are unproven or disproven. I didn't coin the term. To the best of my knowledge, Dr. Robert W. Donnell did nine years ago. However, I adopted it with a vengeance, so much so that a lot of people think I coined the term. In any case, I first began sounding the alarm about the infiltration of quackery like acupuncture, "energy medicine," naturopathy, homeopathy,…
oracknows | March 6, 2017I've been blogging fairly regularly about Houston cancer quack Dr. Stanislaw Burzynski since 2011, and now the story is over...sort of. Unfortunately, as you will see, the ending is far from ideal. It is, however, somewhat better than I had feared it might be. What I'm referring to, of course, is the final ruling of the Texas Medical Board regarding Dr. Burzynski, the Houston cancer doctor who has been a frequent topic of this blog because of his practices of charging desperate cancer patient tens (or even hundreds) of thousands of dollars for his "antineoplastons" (ANPs) and, later, what he…
oracknows | February 24, 2017There are a thousand crappy studies out there carried out with the explicit (although often unspoken) goal of demonizing vaccines by "proving" that they cause autism. Indeed, over the last 12+ years that I've been blogging here, I've deconstructed more such studies than I can remember—or would care to remember if I could. Unfortunately, if there's one thing I've learned about some of these studies, it's that they're like the killers in 1980s slasher flicks. You remember them? Killing machines like Jason Voorhees or Michael Myers, who mowed through teens misbehaving (often by having sex) for…
oracknows | February 17, 2017I like to refer to homeopathy as The One Quackery To Rule Them All, so much so that I almost always call it that within the first two paragraphs of any post I write about some tasty bit of homeopathy pseudoscience. It's also a wonderful tool for teaching critical thinking because it's easy to explain and people grasp intuitively why homeopathy is pseudoscience when it's explained properly to them. Basically, it's because of homeopathy's two laws. The first is the Law Similars, which states that, relieve a symptom, you must use something that causes the symptom. It's nonsense. There's no…
oracknows | February 13, 2017One of the overarching themes of this blog, if not the overarching theme, is to expose and combat the infiltration of quackery into medicine. What I'm referring to, of course, is the phenomenon that's risen over the last 25 years or so in which various pseudoscientific alternative medicine therapies (but I repeat myself) have found increasing acceptance, thanks largely to a major lack of critical thinking skills among both patients and, worse, the physicians who have embraced modalities such as acupuncture, naturopathy, chiropractic, and the like. In fairness, it's not just a lack of critical…
What if, rather than being too stringent about drug approval, the FDA is not being stringent enough?
oracknows | February 12, 2017There is a belief that is very prevalent among policymakers right now, particularly Republican policymakers, that the key impediment to drug development is the Food and Drug Administration. According to this narrative, the FDA is an overly strict, overly bureaucratic, and rigid organization that is the main barrier keeping fantastic cures to all sorts of deadly and debilitating diseases from flowing to the people at a reasonable price. The basic idea, as I've discussed many times, is that, if only the FDA would get out of the way, universities and pharma would be free to open the floodgates…
oracknows | January 29, 2017About a week ago, I happened upon a number of stories about a study and project that demonstrates a key difference between science and pseudoscience. They had titles like, "Rigorous replication effort succeeds for just two of five cancer papers" (Science), "Cancer reproducibility project releases first results: An open-science effort to replicate dozens of cancer-biology studies is off to a confusing start" (Nature), and "What Does It Mean When Cancer Findings Can't Be Reproduced?" (NPR). Basically, these stories all reference a review of the initial results of the Reproducibility Project in…
oracknows | January 25, 2017One of the core beliefs of the antivaccine movement is that there is an "autism epidemic." The observation that autism prevalence has been climbing for the last two to three decades led some parents with autistic children to look for a cause, specifically an environmental cause, for autism. Because several vaccines are given in the age range when children are typically diagnosed with autism, they fell victim to the all-too-human tendency to confuse correlation with causation and latch on to vaccines as the main cause of their child's autism. Then, when these parents banded together, they…
oracknows | January 19, 2017So I was distracted yesterday from what I had intended to write about by an irresistible target provided me courtesy of Toby Cosgrove, MD, CEO of The Cleveland Clinic, who bemoaned all those nasty pro-science advocates who had had the temerity to link the antivaccine rant by the director of the Clinic's Wellness Institute to the quackery practiced there of whose affinity for antivaccine quackery Cosgrove appears to be oblivious. So I took care of that target, and now I'm back to the topic I had wanted to apply some Insolence to. Yes, there was no way I was going to allow this pseudoscientific…
oracknows | January 5, 2017If there's one thing that proponents of "integrative medicine" (or, as it's been called in the past, "complementary and alternative medicine," or CAM) take great pains to emphasize whenever defending their integration of prescientific and pseudoscientific medicine into medicine, it's that they do not recommend using "alternative medicine" instead of real medicine but in addition to real medicine. Indeed, even the "gods" of integrative medicine, such as Barrie Cassileth at Memorial Sloan-Kettering Cancer Center, not only emphasize that but actually often take umbrage when it is suggested that…
oracknows | January 2, 2017Well, it's 2017. In a mere 17 days, unreality will become reality, as the most unlikely and terrifying President in my lifetime is sworn in. Consequently, as I was thinking about what I'd like to write about for my first post of the new year, only one thing came to mind. Only one thing that I routinely apply my Insolence, both Respectful and Not-So-Respectful, to achieves the level of unreality that our politics entered in November and will amplify in a little more than two weeks.
Yes, it's time for a reiki post.
OK, I admit it. A reader sent me a hilarious article about the mechanism of…
oracknows | December 28, 2016Quackademic medicine. I didn't invent the term. (Dr. R. W. Donnell did—nearly nine years ago.) However, I sure use it a lot, because it perfectly describes a phenomenon that has proliferated and metastasized throughout the body of academic medicine like the cancer it is. I like to think that, in my own way, I've popularized the word to describe this particular phenomenon. But what it this phenomenon? It is nothing less than the degradation of the scientific basis of medicine through the infiltration of pseudoscience and quackery into medical academia, with academic physicians who otherwise…
oracknows | December 19, 2016Blogging is a funny thing. Sometimes the coincidence involved is epic. For instance, as I do on many Mondays, yesterday I crossposted a modified and updated version of a post from a week ago from my not-so-super-secret other blog. This time around, it just so happened to be a post about what I like to refer to as the placebo narrative. As is my wont, I described in the usual ridiculous level of detail why that narrative is so popular among promoters of pseudoscientific medical treatments and, more importantly, why that narrative is approaches black hole density bullshit. It’s something that…