Clinical trials
oracknows | August 11, 2013Eric Merola alternates between offending me and making me laugh at his antics. Since it's been a couple weeks since I've written anything about the Houston doctor who claims to be able to do so much better against many forms of cancer than conventional medicine, I have to express a bit of gratitude to Mr. Merola for giving me today's topic for blogging. Mr. Merola, as you recall, produced two incredibly bad and deceptive movies lionizing that very same Houston cancer doctor as a brave maverick genius who's been kept down by The Man (i.e., the Texas Medical Board, the FDA, the National Cancer…
oracknows | August 2, 2013"Alternative medicine," so-called "complementary and alternative medicine" (CAM), or, as it's become fashionable to call it, "integrative medicine" is a set of medical practices that are far more based on belief than science. As my good bud and collaborator Mark Crislip so pointedly reminded us last week, CAM is far more akin to religion than science-based medicine (SBM). However, as I've discussed more times than I can remember over the years, both here and at my not-so-super-secret-other blog, CAM practitioners and advocates, despite practicing what is in reality mostly pseudoscience-based…
oracknows | July 22, 2013Time really does fly. It's hard to believe that it's been over a week since I gave my big (to me, at least) talk at TAM. It's equally hard to believe that it's been more than a week since I had the honor of being kicked out of Penn Jillette's Private Rock & Roll Bacon & Doughnut Party because back in February I had had the temerity to question whether it was a good idea for Penn & Teller to appear on The Dr. Oz Show. It was a surreal experience, to be sure, to be cussed out publicly (albeit with no mention of my name), kicked out of Penn's private party, and then to have had Penn…
oracknows | July 17, 2013Believe it or not, I'm going to do Eric Merola (who doesn't particularly like me, to the point of thinking, apparently, that I'm a white supremacist who doesn't like evidence but does like to eat puppies) a favor. Having been away at TAM, somehow I missed this. Well, actually, I didn't miss it, but somehow I forgot to post it. Then when I got home I still forgot to post it. Now there are only three days left (four, counting today) for me to do it; so I'd better get to it. My having forgotten to do this is particularly amazing given the subject of my main stage talk at TAM.
Eric Merola, as you…
oracknows | July 15, 2013As I write this, I'm winging my way home from TAM, crammed uncomfortably—very uncomfortably—in a window seat in steerage—I mean, coach).
I had thought of simply recounting the adventures of the contingent of skeptics with whom I'm associated who did make it out to TAM to give talks at workshops and the main stage and to be on panels, but that seemed too easy. Also Orac is just too damned egotistical, and, besides, it's a four hour flight. Even so, I would be remiss if, before delving into the topic of today's post, I didn't praise Steve Novella, Harriet Hall, and Mark Crislip, for their…
oracknows | July 3, 2013Here we go again.
Oh, well. These things come in waves, and sometimes I have theme weeks. Right now, this week appears to be developing into a week of quackademic medicine involving dubious acupuncture studies. Yesterday, it was acupuncture for lymphedema after breast cancer surgery, a study coming right about what is rapidly becoming the Barad-dûr of cancer quackademia, Memorial Sloan-Kettering Cancer Center. How a hospital that is so awesome in every other way can have such a blind spot bigger than the Eye of Sauron, I don't know, but it does, and the result is a steady stream of…
oracknows | June 7, 2013[NOTE ADDENDUM.]
It's been a (mostly) all Stanislaw Burzynski week. I had been thinking of finishing up with a post about something completely unrelated; that is, until people started sending me a link. Also, because I was out last night with my wife in celebration of our wedding anniversary, I didn't have time for anything that wasn't relatively brief. (Yes, I do realize that "brief" by my standards usually means "under 2,000 words." OK, maybe under 1,500.) So, what the heck? I'll finish the week with one more post and then try to start fresh next week. I need a a break from all things…
oracknows | June 6, 2013It was a busy day yesterday, and I had less time than usual to attend to the blog, but that's OK. This random thought popped into my head after spending the last three days writing about Stanislaw Burzynski, first reviewing Eric Merola's hagiography and infomercial about him, then seeing how well the BBC did in its news series Panorama in covering the patient-endangering phenomenon that is the Burzynski Clinic, and, finally, noting that what Burzynski said about his clinical trials doesn't necessarily jibe with what his SEC filings about his research institute say about them. Looking to move…
oracknows | June 5, 2013I realize that I've been focusing on Stanislaw Burzynski the last couple of days, but it's just been one of those weeks. Between the release of Eric Merola's latest paean to the Brave Maverick Doctor and BBC Panorama's report on Burzynski and his activities, it's been an eventful week. My review of the second Burzynski movie and the Panorama report explain a lot, but there are some loose ends left over. So I might as well take care of that today before resuming regular blogging topics. (Yes, I know Stanislaw Burzynski is a regular blogging topic, but too much of a bad thing can get tiresome,…
oracknows | June 2, 2013Well, I've finally seen it, and it was even worse than I had feared. One might even say that watching it was like repeatedly smacking my head into a brick wall. It felt so good when it finally stopped.
I'm referring, of course, to Eric Merola's latest cinematic "effort. Ever since it was revealed that ric Merola's planned to make a sequel to his 2010 propaganda "documentary" about Stanislaw Burzynski, Burzynski The Movie: Cancer Is Serious Business, whose rank stupidity provided me with copious blogging material, I've finally actually seen the finished product, such as it is. Of course,…
oracknows | May 20, 2013Just when I thought I was out, they pull me back in.
OK, I know I use that line entirely too much, but I also don't really care. When something fits, wear it. And if it doesn't fit, you must acquit. Sorry, I'll stop. I'm in a weird mood as I write this. But it's really hard not to get into a weird mood after reading the lastest bit by that crank to rule all cranks, that quack who tries to rule all quacks, Mike Adams, founder of NaturalNews.com. Last week, he laid down the vile stupid fast and furious to attack Angelina Jolie's decision to undergo bilateral prophylactic mastectomy. It was hard…
oracknows | May 19, 2013That naturopathy is a veritable cornucopia of quackery mixed with the odd sensible, science-based suggestion here and there is not in doubt, at least not to supporters of science-based medicine (SBM). However, what naturopaths are very good at doing is representing their pseudoscience as somehow being scientific and thus on par with actual SBM. So how do they accomplish this? Certainly, it's not through the validation of any of the cornucopia of pseudoscience and quackery that naturopaths apply to their patients as though picking "one from column A and one from column B" from a proverbial…
oracknows | May 13, 2013I'm not alone in pointing this out, but if there's one thing about research and clinical trials into "complementary and alternative medicine" (CAM) that has become very apparent to me over the years, it's that the more rigorous the study the less likely it is to show an effect. In normal research, the usual progression in clinical research goes from small pilot and observational studies to small to medium-sized randomized studies, ultimately culminating in large randomized, double-blind studies that are tightly controlled to eliminate as many potential biases and confounders as possible, as…
oracknows | May 8, 2013A key pillar of the Stanislaw Burzynski antineoplaston marketing machine, a component of the marketing strategy without which his clinic would not be able to attract nearly as many desperate cancer patients to Houston for either his antineoplaston therapy (now under a temporary shutdown by the FDA that, if science were to reign, will become permanent) or his "personalized gene-targeted cancer therapy," which Burzynski represents as a discovery of his that large NCI-designated comprehensive cancer centers like M.D. Anderson or Memorial Sloan-Kettering are only now starting to copy, is the…
oracknows | May 8, 2013I've been very, very critical of a self-proclaimed cancer doctor named Stanislaw Burzynski, who is not an oncologist but somehow has managed over the last 36 years to treat patients with unapproved cancer drugs, list dozens of phase 2 clinical trials in ClinicalTrials.gov but never publish a completed one (at least to this date), and have his patients pay up up to several hundred thousand dollars for the privilege of being treated on one of his clinical trials. Meanwhile, the Burzynski Clinic and Burzynski Research Institute flout the regulations protecting human subjects in research. Even…
oracknows | May 6, 2013Stem cells are magical, mystical things that can't be explained.
At least, if you listen to what docs and "practitioners" who run stem cell clinics in various parts of the world, usually where regulation is lax and money from First World clientele is much sought after, that's what you could easily come to believe. Unfortunately, it's not just Third World countries in which "stem cell clinics" have proliferated. For instance, they are not nearly uncommon enough in Europe. The example that is most troubling right now is Italy, and the reason is that there is currently a law being considered…
oracknows | May 2, 2013In the United States, the federal government has long had a prominent role in funding science research. Be it the $30 billion a year or so that funds the National Institutes of Health or the $5 or $6 billion a year allotted to the National Science Foundation, the government funds a lot of basic and applied research, and this is in general a good thing. The number of discoveries and advances that have come out of this funding have well repaid the investment and much more. There is, however, a downside to this funding that's a pretty obvious consequence any time the government funds anything,…
oracknows | April 29, 2013So now we know.
Back when it was announced that the second Burzynski movie by Eric Merola would be screened at the Newport Beach Film Festival on April 27, Merola announced that there would be a "special celebrity guest." Those of us who have been following Burzynski for a while scratched our heads, not knowing who it could likely be. We considered and rejected multiple possibilities: Suzanne Somers, Ralph Moss, and many others. Well, now we know who would be giving the celebrity endorsement for the Burzynski Clinic, and, no, it's not Josh Duhamel.
It's Fabio Lanzoni:
Yes, that Fabio. The…
oracknows | April 19, 2013If there is one aspect of cranks that is almost universal (besides the aforementioned tendency to want to prove themselves through things like "live televised debates"), it's a tendency to want to shut down the criticism of its opposition. True, such a tendency is a human trait as well and used far too often by, say, corporations, but it's one that seems to be cranked up to 11 and beyond, as they say, in cranks.
We've seen it time and time again. Most often, it takes the form of some sort of legal bullying, such as when the British Chiropractic Association bit off more than it could chew by…
oracknows | April 14, 2013About a month ago, Eric Merola screened his second movie about "brave maverick doctor" Stanislaw Burzynski, Burzynski: Cancer Is A Serious Business, Part 2 (henceforth referred to as "Burzynski II"), a screening that Brian Thompson and an unnamed colleague from the James Randi Educational Foundation (JREF) attended, took notes, and even managed to ask a question. At the time, I took advantage of Brian's awesome commentary about his experience on the JREF Swift Blog, his copious notes, and my read on Eric Merola's trailers for the movie, what he said in the first movie, and his own promotional…