Pharmacology

Do you feel unsatisfied, irritated, impatient with yourself? Ever? Do you not always enjoy activities that you once enjoyed? Do you feel older than you used to be? Stop right there—you could be suffering from a serious problem called Dysphoric Social Attention Consumption Deficit Anxiety Disorder (DSACDAD). Don't be afraid: millions do. And help is on the way, in the form of—what else?—a pill. That would be Havidol®, the trade name of Avafynetime HCl. As the Havidol package insert reminds us, "No prescription drug can promise endless happiness." But with Havidol, you can achieve the "terminal…
Wasn't able to get off an original post today so I'll direct Terra Sig readers to an excellent interview written by Carl Zimmer. As Carl writes, Discover chose Jay Keasling as their scientist of the year and asked me to interview him. Keasling, who directs the Berkeley Center for Synthetic Biology, is trying to get either E. coli or yeast to crank out a powerful malaria drug normally only made by the sweet wormwood plant. I had already been getting familiar with Keasling's work, since it is a great example of the sort of work that's being done on E coli, the subject of my book. So it was a…
If you've been working in this field for any period of time, cocktail party discussions or talks with students invariably turn to nature's greatest trove of biologically-active compounds, those that act on the central nervous system (CNS) as stimulants, euphorics, and hallucinogens. So, over the last couple of days, I've been enjoying the posts by my relatively new compatriot here at ScienceBlogs, SciBling for short, The Molecule of the Day. I have no clue as to who he/she is or where they are other than it is written, "by a chemist who enjoys rambling about the relationship between…
Most of last week's posts were about music, so I thought I'd round out the holy trinity of sex, drugs, and rock 'n' roll. Traveling this weekend gave me an opportunity to indulge in one of my secret guilty pleasures: reading USA TODAY. First up, as it were, is Kitty Bean Yancey's story on the opportunity for Atlanta-based passengers to join the mile-high club in a private plane for just $299: Q: Who goes on these flights? A: Couples from 18 and 19 up to their 60s. I've taken between 75 and 100 in five years. I've had people fly in from New York, New Jersey and Miami just to do the mile-high…
The wimpy approval of OTC status today for Plan B emergency contraception only for women 18 and older has me nonplussed. I've been disgusted by the intrusion of politics into science and medicine on this issue for quite some time. As some Terra Sig readers know, a major network news outlet keeps the real Dr Pharmboy on their experts list for commentary on pharmacotherapy issues but my exact comments rarely make it on-air. Perhaps these will be inflammatory enough to get a call to be on this time, and then you'll all know who I am. (No, I am not Dr Raymond Woosley, but I wish I were.) So here…
Yes, I know that I am late with The Friday Fermentable, but this pharmacologist couldn't pass up the following blogthing on a lazy Saturday morn: Your Personality Is Like Ecstasy You're usually feeling the love for the world around you - you want to hug everyone. And while you're usually content to sit back and view the world with wonder... Sometimes your world becomes very overwhelming and a little scary. What Drug Is Your Personality Like? Definitely the first blog quiz I've ever taken that nailed me. Hat tip: La Blonde Parisienne at Daily Hysteric
While we're on the topic of death and acknowledging that 70-ish is a life well-lived, I'd note that experimental pharmacologist and legendary gonzo journalist, Dr Hunter S Thompson, would have been 69 yesterday. His widow, Anita, keeps a blog at their fortified Owl Farm estate and posted this loving tribute to The Good Doctor yesterday. Although we were live-blogging from Aspen last week, we're certainly not the kind of folks to go poking around in Mrs Thompson's business up Woody Creek Road - plus, I really do fear the remaining explosives, especially with a 4-year-old running wild and…
Monday's contest to win $50 decoding the chemical and historical nature of the Terra Sigillata banner masthead got such a response that I didn't even expect it. Amazingly, one entrant answered 4 of the 5 questions correctly, with the 5th being closest of anyone. I'll be contacting the lucky feller forthwith regarding delivery of his fifty American dollars. The answers will follow in subsequent posts, but here are the questions once again of you care to exercise your mind: 1. What is the complete name of the dude on the righthand side of the banner and why do you think I picked him to as the…
I've never properly acknowledged the commercial artist, Mr Brien O'Reilly of SaBOR Design, who designed the content-rich, scientific eye-candy banner in the masthead above for the Sb version of Terra Sigillata. So, I'd like to kick off the week raising awareness of the banner and advertising Mr O'Reilly's talents and services by asking some questions of you about the design elements of the banner. And, since I know that many readers of Terra Sig are poor graduate students or postdoctoral fellows, I'm well-aware that nothing gets your attention like cash-for-knowledge. (Well, yes, free…
What would you do if someone told you it was possible to get merrily drunk with none of the unsavory consequences? No hangovers, no unidentifiable party injuries, no "where-did-this-tattoo-come-from" screams the following morning? What if you also heard that there was a pill you could pop to sober you up quickly, giving you the option to drive home after a night at the bar, or at the very least, not pass out on the subway and end up in a place you can't even pronounce? Personally, my first reaction would be to drop my half-drunk beer, hug everyone within a half-mile radius while singing the…
Would you rather be miserable and smitten, or serene and passionless? If you're suffering from depression and your doctor has prescribed SSRIs (or serotonin selective reuptake inhibitors) these are your options, according to anthropologist Helen Fisher. Fisher, who has been called the "doyenne of desire," believes that Prozac and other SSRIs are robbing us of our ability to form satisfying romantic relationships. It's no secret that SSRIs squelch the sex drive. Over the past decade, Prozac's libido-dampening effects have become such a part of the cultural conversation that the issue was even…